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  • Chemokine Products
    • Biotinylated Chemokines
    • Unmodified Chemokines
  • Chemokine Protocols
    • Flow Cytometry with Biotinylated Chemokines
    • ELISA with Biotinylated Chemokines
    • Transwell Migration Assay
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Chemokines by ChemoTactics

Custom, Low Cost Chemokines

Delivering the highest quality chemokine reagents to Academic, Pharmaceutical, and Biotech industries. ChemoTactics utilizes newly patented technology to develop modified and unmodified chemokines for advanced research needs.

Explore Products

Chemokine Protein Products
High-quality recombinant chemokines empowering preclinical research.
Contact us at info@chemotactics.com for large scale and custom inquiries. 

Fast Shipment World-Wide

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Human
​Chemokines


CCL2 (MCP-1)
CCL3 (MIP-1α)
CCL4 (MIP-1β)
CCL5 (Rantes)
CCL7 (MCP-3)
CCL14 (HCC-1)
CCL19 (MIP-3β)
CCL27 (CTACK)
CCL28 (MEC)
CXCL8 (IL-8)
CXCL10 (IP-10)

CXCL12 (SDF-1α)
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Biotinylated Human
​Chemokines


CCL2 (MCP-1)-Biotin
CCL3 (MIP-1α)-Biotin
CCL4 (MIP-1B)-Biotin
CCL5 (Rantes)-Biotin
CCL7 (MCP-3)-Biotin
CCL14 (HCC-1)-Biotin
CCL19 (MIP-3β)-Biotin
CCL28 (MEC)-Biotin
CXCL8 (IL-8)-Biotin

CXCL12 (SDF-1α)-Biotin
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Mutant Human
​Chemokines
Mutant isoforms that do not aggregate, bind GAGs, or act as agonists.
​
  • CCL2 (MCP-1) - Antagonist and Monomeric 
  • CCL5 (Rantes) - Antagonist, tetrameric, and dimeric 
  • CCL3 (MIP-1α) - Monomeric forms 
  • CXCL12 (SDF-1α) - Antagonist forms 


Please contact us for mutant orders

We Rigorously Test All Products
to Ensure High Quality


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U937 cells expressing endogenous CXCR4 were stimulated with increasing concentrations of SDF-1α after a 90-minute incubation with calcium dye at 37oC.  The maximum response was plotted as a function of the ligand concentration (Red: wild type; Blue: biotinylated). 
Cells expressing recombinant CCR2 were assayed for migration through a transwell bare filter at various concentrations of MCP-3.  The responses are expressed as the % of total input cells (Red: wild type; Blue: biotinylated).

Create Custom Assays with
​Biotinylated Chemokines


Flow Cytometry with Biotinylated Chemokines

A.  Uptake of 20nM CXCL12-biotin by U937 cells in the presence (red trace) and absence (cyan) of a CXCR4 inhibitor, AMD 3100.  U937 cells are not stained by streptavidin-PE in the absence of CXCL12-biotin (orange).
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B.  Uptake of 20nM CCL2-biotin by THP1 cells (dark green trace) is abolished by the addition of CCL7 (orange) but not CCL14 (light green), suggesting a CCR2-specific internalization.  THP1 cells are not stained in the absence of CCL2-biotin (cyan).

Institutes Using Chemokines from ChemoTactics


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CXCR4 X-Ray Crystal Structure PDB: 3ODU

Bristol Myers Squib, USA
UC San Diego, CA USA
Hannover Medical Center, Germany
The Moores Cancer Center, CA USA
The Scripps Research Institute (TSRI) La Jolla, CA USA
University of Piedmont, Italy
Regeneron, USA
Sanford Consortium for Regenerative Medicine, CA USA
Genentech, USA
University of Utah, UT USA
University of Monash, Australia
University of Houston, TX USA
UC Berkley, CA USA
Tel Aviv University, Israel
Pfizer Global R & D, USA
University of Georgia, GA USA
NIBST, United Kingdom
Case Western Reserve University, USA
Merck Serono Geneva Research Center, Switzerland
Department of Veterans Affairs Medical Center, USA
Uppsala University, Sweden
Plus Many More

Product Catalog
Product Catalog Contents
  • ChemoTactics Introduction and Background Information 
  • Learn about the various types of assays biotinylated chemokines can be used in 
  • Updated Product and Pricing List
  • Detailed product descriptions
  • Chemokine Assay Protocols
  • Purchasing Conditions and Distributor Information

Request a catalog by contacting us today

CXCL12 (SDF-1a)

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ChemoTactics, Inc. 
6076 Corte Del Cedro
Carlsbad, CA 92011 USA

Phone: (858)-412-0485

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