ChemoTactics, Inc specializes in the efficient production of high quality chemokine reagents available to chemokine researchers worldwide.
We offer high quality chemokine protein reagents, at affordable prices to reduce overbearing costs of conducting research. Our products include modified chemokines such as biotinylated and mutant isoforms for in vivo, pharmacological, and microscopy studies.
Our expertise lies in recombinant chemokine production which can also be applied to other signaling proteins with high levels of activity. Our core technology has been utilized to help solving multiple crystal structures of CXCR4 .
Please contact us if you are interested purchasing chemokines, distributing chemokines, or would like custom products.
Research Institutes using Our Chemokines
CXCR4 X-Ray Crystal Structure
PDB: 3ODU 
Bristol Myers Squib, USA
UC San Diego, CA USA
Hannover Medical Center, Germany
The Moores Cancer Center, CA USA
The Scripps Research Institute (TSRI) La Jolla, CA USA
University of Piedmont, Italy
Sanford Consortium for Regenerative Medicine, CA USA
University of Utah, UT USA
University of Monash, Australia
University of Houston, TX USA
UC Berkley, CA USA
Tel Aviv University, Israel
Pfizer Global R & D, USA
University of Georgia, GA USA
NIBST, United Kingdom
Case Western Reserve University, USA
Merck Serono Geneva Research Center, Switzerland
Department of Veterans Affairs Medical Center, USA
Selected Publications with Chemokines Produced by ChemoTactics
- "The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5)". Torretta S., Colombo G., Travelli C, Boumya S., Lim D., Genazzani A., Brolla A.
Cells 2020 Feb; 9(2):496. doi 10.3390/cells9020496 PMID: 32098202
- Wu, B., Chien, E.Y., Mol, C.D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R., Brooun, A., Wells, P., Bi, F.C., Hamel, D.J., Kuhn, P., Handel, T.M., Cherezov, V., Stevens, R.C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science, 2010. 330: 1066-1071. PMID: 20929726
- Ervin E. Kara, Iain Comerford, Cameron R. Bastow, Kevin A. Fenix, Wendel Litchfield, Tracey M. Handel, and Shaun R. McColl. Distinct chemokine receptor axes regulate T helper 9 cell trafficking to allergic and autoimmune inflammatory sites. J Immunol., 191:1110-1117, 2013. PMID: 23797668
- M. O'Hayre, C.L. Salanga, T.J. Kipps, D. Messmer, P.C. Dorrestein, T.M. Handel (2010) Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomic Analysis. PLoS One. 5:e11716. PMID:
- T.M. Handel, Z. Johnson, M. Mack, R. Cirillo, V. Muzio, M. Teixiera, M. Déruaz, F. Borlat, T.N.C. Wells, and A.E.I. Proudfoot (2008). An Engineered Monomer of CCL2 has Anti-inflammatory Properties Emphasizing the Importance of Oligomerization for Chemokine Activity In Vivo. J Leukocyte Biology. 84(4):1101-8. PMID: 18662971