About ChemoTactics

ChemoTactics was founded in 2013 by chemokine structural biologists and pharmacologists at UC San Diego. Our mission is to provide the chemokine research community with affordable high-quality chemokine reagents. We aim to create novel tools and assays to enable our customers to develop the next generation of advanced therapeutics.

We specialize in the efficient production of high-quality human chemokines for research scientists worldwide. Our products include both unmodified and biotinylated chemokines for flow cytometry, in vivo, drug development, imaging, cell characterization and other techniques.

Our expertise lies in recombinant chemokine production which can also be applied to other signaling proteins with high levels of activity. Our chemokines were utilized to help solve the multiple crystal structures of CXCR4 [7].

What are Chemokines?

Chemokines are a class of cytokines responsible for the process of cell movement called chemotaxis. These small secreted signaling proteins act as chemical messengers on G-protein coupled chemokine receptors. In humans, there are over 50 chemokines and 19 chemokine receptors known to date.

As chemokines affect various physiological processes involving cell movement they are vital to our overall health and homeostasis. One important example is maintaining the body's defense mechanisms by guiding immune cells to specific sites in the body where they are needed to combat infections or address tissue damage.

Our Products and Services

Chemokine Proteins

We have off the shelf biotinylated and unconjugated chemokine proteins for research use. We can also provide fluorescent and mutant chemokines upon request.

Chemokine Products

Protein Expression Services

We offer protein expression and consulting services for all types of proteins and expression systems. Please send us an email to set up a meeting and discuss your specific needs ([email protected]).

Research Services

Research Institutes using Our Chemokines

CXCR4 X-Ray Crystal Structure
PDB: 3ODU [7]

Istituto Italiano di Tecnologia, Genova, Italy
Cold Spring Harbor Labs, NY, USA
Bristol Myers Squib, USA
Caltech, CA USA
UC San Diego, CA USA
Hannover Medical Center, Germany
UCSD Moores Cancer Center, CA USA
The Scripps Research Institute (TSRI) La Jolla, CA USA
University of Piedmont, Italy
Regeneron, USA
Sanford Consortium for Regenerative Medicine, CA USA
Genentech, USA
University of Utah, UT USA
University of Monash, Australia
University of Houston, TX USA
UC Berkley, CA USA
Tel Aviv University, Israel
Pfizer Global R & D, USA
University of Georgia, GA USA
NIBST, United Kingdom
Case Western Reserve University, USA
Merck Serono Geneva Research Center, Switzerland
Department of Veterans Affairs Medical Center, USA
Uppsala University, Sweden
Plus Many More

Selected Publications with Chemokines Produced by ChemoTactics

Pisani, A., Donno, R., Valenti, G., Pompa, P. P., Tirelli, N., & Bardi, G. (2022). Chemokine-decorated nanoparticles target specific subpopulations of primary blood mononuclear leukocytes. Nanomaterials, 12(20), 3560. https://doi.org/10.3390/nano12203560
Pisani, A.; Donno, R.; Gennari, A.; Cibecchini, G.; Catalano, F.; Marotta, R.; Pompa, P.P.; Tirelli, N.; Bardi, G. CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration. Nanomaterials 2020, 10, 2304. https://doi.org/10.3390/nano10112304
Wang Z, Moresco P, Yan R, Li J, Gao Y, Biasci D, Yao M, Pearson J, Hechtman JF, Janowitz T, Zaidi R, Weiss MJ, Fearon DT. Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack. PNAS Jan 2022 Vol. 119 No. 4. https://doi.org/10.1073/pnas.2119463119
Chatterjee, T., Johnson-Buck, A. Walter, NG. Highly sensitive protein detection by aptamer-based single-molecule kinetic fingerprinting. Biosensors and Bioelectronics. Vol 216 15 Nov 2022. https://doi.org/10.1016/j.bios.2022.114639
Zhikai Wang, Ran Yan, Jiayun Li, Ya Gao, Philip Moresco, Min Yao, Jaclyn F. Hechtman, Matthew J. Weiss, Tobias Janowitz, Douglas T. Fearon. Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy. bioRxiv 776419; doi: https://doi.org/10.1101/776419. Posted: September 4, 2020
Torretta S., Colombo G., Travelli C, Boumya S., Lim D., Genazzani A., Brolla A. The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5). Cells 2020 Feb; 9(2):496. doi 10.3390/cells9020496 PMID: 32098202
Wu, B., Chien, E.Y., Mol, C.D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R., Brooun, A., Wells, P., Bi, F.C., Hamel, D.J., Kuhn, P., Handel, T.M., Cherezov, V., Stevens, R.C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science, 2010. 330: 1066-1071. PMID: 20929726
Ervin E. Kara, Iain Comerford, Cameron R. Bastow, Kevin A. Fenix, Wendel Litchfield, Tracey M. Handel, and Shaun R. McColl. Distinct chemokine receptor axes regulate T helper 9 cell trafficking to allergic and autoimmune inflammatory sites. J Immunol., 191:1110-1117, 2013. PMID: 23797668
M. O'Hayre, C.L. Salanga, T.J. Kipps, D. Messmer, P.C. Dorrestein, T.M. Handel (2010) Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomic Analysis. PLoS One. 5:e11716. PMID:
20661426
T.M. Handel, Z. Johnson, M. Mack, R. Cirillo, V. Muzio, M. Teixiera, M. Déruaz, F. Borlat, T.N.C. Wells, and A.E.I. Proudfoot (2008). An Engineered Monomer of CCL2 has Anti-inflammatory Properties Emphasizing the Importance of Oligomerization for Chemokine Activity In Vivo. J Leukocyte Biology. 84(4):1101-8. PMID: 18662971