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What are Chemokines?
Chemokines are a class of cytokines that that induce cell migration across a multitude of cell types and signal via GPCR chemokine receptors. Chemokines are typically less than 10kDa in size and have signature disulfide bonds that are required for them to be functional.
Chemokines and their receptors are proteins best known for their role in monitoring the immune system, where they control the migration and activation of immune cells to resolve problems such as infections and cancerous cells. An example of a chemokine’s actions are to direct the movement of an immune cell (green) from the blood to a specific site of bacterial infection.
Chemokines and their receptors are proteins best known for their role in monitoring the immune system, where they control the migration and activation of immune cells to resolve problems such as infections and cancerous cells. An example of a chemokine’s actions are to direct the movement of an immune cell (green) from the blood to a specific site of bacterial infection.
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This signaling occurs through the activation of specific chemokine receptors on the immune cells by chemokines (blue and purple).
Chemokines induce the migration of cells from one location to another via a concentration gradient and can recruit, enrich and isolate specific cell types from tissues and whole organisms. The signaling of chemokines is complex regulated through additional binding proteins as well as glycosaminoglycans (GAGs). When chemokines and their receptors are not regulated properly, many pathologies can result including Inflammatory Disease, Atherosclerosis, Cancer and AIDS. Thus, there is significant interest in understanding how they function in order to develop therapies to block their activities. |
Keep up with all of the most recent applications from researchers around the world that are using ChemoTactics chemokines in their publications. Below are some of the most recent examples.
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CXCL12 suppresses T cell response in carcinoma immunotherapy
Wang, Z. et al. PNAS 2022 Jan 25; 119(4): e2119463119
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Creation of CXCL12 coated nanoparticles for drug delivery
Pisani, A. et al. Nanomaterials 2020, 10, 2304.
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Natural CCR5 antagonist eNAMPT identified in cancer cells
Torretta, S. et al. Cells 2020, 9, 496.
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Blogs & Disease Areas
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