Chemokines are a family of small proteins secreted by cells in the body that play a crucial role in immune responses and inflammation. They act as chemical messengers, guiding immune cells to specific sites in the body where they are needed to combat infections or address tissue damage. Chemokines help regulate the movement and recruitment of immune cells, contributing to the body's defense mechanisms and overall immune function. ChemoTactics produces recombinant chemokine reagents for research use.
Proudly made in the USA.
High-quality recombinant chemokines empowering preclinical research.
Contact us at info@chemotactics.com or 858-412-0485 for large scale and custom inquiries.
High-quality recombinant chemokines empowering preclinical research.
Contact us at info@chemotactics.com or 858-412-0485 for large scale and custom inquiries.
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Mutant Human
Chemokines Mutant isoforms that do not aggregate, bind GAGs, or act as agonists.
Please contact us for mutant orders |
We Rigorously Test All Products
to Ensure High Quality
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U937 cells expressing endogenous CXCR4 were stimulated with increasing concentrations of SDF-1α after a 90-minute incubation with calcium dye at 37oC. The maximum response was plotted as a function of the ligand concentration (Red: wild type; Blue: biotinylated).
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Cells expressing recombinant CCR2 were assayed for migration through a transwell bare filter at various concentrations of MCP-3. The responses are expressed as the % of total input cells (Red: wild type; Blue: biotinylated).
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Create Custom Assays with
Biotinylated Chemokines
Flow Cytometry with Biotinylated Chemokines
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A. Uptake of 20nM CXCL12-biotin by U937 cells in the presence (red trace) and absence (cyan) of a CXCR4 inhibitor, AMD 3100. U937 cells are not stained by streptavidin-PE in the absence of CXCL12-biotin (orange).
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B. Uptake of 20nM CCL2-biotin by THP1 cells (dark green trace) is abolished by the addition of CCL7 (orange) but not CCL14 (light green), suggesting a CCR2-specific internalization. THP1 cells are not stained in the absence of CCL2-biotin (cyan).
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Institutes using our Chemokines
CXCR4 X-Ray Crystal Structure
PDB: 3ODU
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Cold Spring Harbor Labs, NY, USA
Bristol Myers Squib, USA UC San Diego, CA USA Hannover Medical Center, Germany The Moores Cancer Center, CA USA The Scripps Research Institute (TSRI) La Jolla, CA USA University of Piedmont, Italy Regeneron, USA Sanford Consortium for Regenerative Medicine, CA USA Genentech, USA University of Utah, UT USA University of Monash, Australia University of Houston, TX USA UC Berkley, CA USA Tel Aviv University, Israel Pfizer Global R & D, USA University of Georgia, GA USA NIBST, United Kingdom Case Western Reserve University, USA Merck Serono Geneva Research Center, Switzerland Department of Veterans Affairs Medical Center, USA Uppsala University, Sweden Plus Many More |
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Product Catalog
Product Catalog Contents
Request a catalog by contacting us today
- ChemoTactics Introduction and Background Information
- Learn about the various types of assays biotinylated chemokines can be used in
- Updated Product and Pricing List
- Detailed product descriptions
- Chemokine Assay Protocols
- Purchasing Conditions and Distributor Information
Request a catalog by contacting us today
